Wethersfield is a town located in Hartford County, Connecticut. It is located immediately south of Hartford along the Connecticut River. Its population was 27,298 at the time of the 2020 census. Many records from colonial times spell the name "Weathersfield" and "Wythersfield," while Native Americans called it Pyquag. "Watertown" is a variant name. The neighborhood known as Old Wethersfield is the state's largest historic district, spanning 2 sq mi (5.2 km2) and containing 1,100 buildings, dating to the 17th, 18th and 19th centuries. The town is primarily served by Interstate 91.