The Karpeles Manuscript Library Museum is a museum in Jacksonville, Florida, one of fifteen Karpeles Manuscript Library Museums in the United States, all housed in repurposed old buildings. Other locations of Karpeles Museums include Buffalo, NY; Charleston, SC; Duluth, MI; Newburgh, NY; Santa Barbara, CA; Tacoma, WA; Shreveport, LA; Fort Wayne, IN; Alvin, TX; Rock Island, IL; St. Louis, MO; Gloversville, NY; Pittsburgh, PA; and Great Falls, MT. Karpeles Manuscript Library Museums display manuscripts and documents from the private collection of David and Marsha Karpeles, the world's largest such collection, as well as art exhibits. The museum opened in 1992 in the former First Church of Christ, Scientist building in Jacksonville's Springfield neighborhood. The Classical Revival structure, constructed in 1921, is a contributing property in the Springfield Historic District and is listed as No. SP-61 by the Jacksonville Historic Landmarks Commission.