The Nathan Lester House is a historic house museum at 153 Vinegar Hill Road in the Gales Ferry section of Ledyard, Connecticut. Built in 1793, it is a well-preserved example of an unpretentious late 18th-century farmhouse, and one of the few houses of that age left in the town. It is located on over {{convert|156 acres of land, now owned by the town, which serves as a park and conservation land with trails.