The National Mississippi River Museum & Aquarium is a museum located in Dubuque, Iowa, USA. The museum is a property of the Dubuque County Historical Society, which also operates the Mathias Ham Historic Site. The museum has two buildings on its riverfront campus: the Mississippi River Center and the National River Center. The museum originally opened as the Fred W. Woodward Riverboat Museum on July 18, 1982 before being expanded and re-organized into its current form. The museum is an affiliate of the Smithsonian Institution, and is accredited by the American Alliance of Museums (AAM) and the Association of Zoos and Aquariums (AZA).