Oklahoma Frontier Drug Store Museum was established in 1992 and located in Guthrie, Oklahoma. The museum has an occupancy in the Gaffney Building constructed in 1890 and integral to the Guthrie Historic District. The museum has nineteenth century and early twentieth century apothecary artifacts related to alchemy, elixirs, esoteric pharmacies, herbal tonics, tinctures, and traditional medicines for confronting the struggles with the diseases and epidemics of the 19th century.