The Sherbrooke Nature and Science Museum (French: Musée de la nature et des sciences de Sherbrooke) is a natural history and science museum in Sherbrooke, Quebec, Canada. It is located at 225 Frontenac Street in downtown Sherbrooke. The museum receives funding from the City of Sherbrooke, the Quebec Ministry of Culture and Communications, the Department of Canadian Heritage as well as sponsorships, special grants and private funding.